Combination of metformin and MTP inhibitor

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专利权人:

ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ

发明人:

ウエイス，エバ・アリナ,バン・ニユーテン，リユク・ギローム・エム,ウエイス,エバ・アリナ,バン・ニユーテン,リユク・ギローム・エム

申请号：

JP2010542626

公开号：

JP5571000B2

申请日:

2009.01.15

申请国别(地区):

JP

年份:

2014

代理人:

摘要：

The present invention relates to a combination of the anti-diabetic drug metformin and the MTP (microsomal triglyceride transfer protein) inhibitor (+)-phenyl-(4-{4-[(4&prime；-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-piperidin-1-yl)-acetic acid methyl ester and the use thereof for combined administration in the treatment or prevention of diabetes mellitus type 2 conditions. The invention further relates to products containing as first active ingredient metformin and as second active ingredient the MTP inhibitor (+)-phenyl-(4-{4-[(4&prime；-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-piperidin-1-yl)-acetic acid methyl ester, as combined preparations for simultaneous or sequential use in the treatment or prevention of diabetes mellitus type 2； and to related pharmaceutical compositions and uses.

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