Charles Ian Robert Johnson,Sara Louise Jenkins,Colin Martin McKee,David John Evans
申请号：
US15324517
公开号：
US20170196990A1
申请日:
2015.07.08
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Disclosed is a solid phase method of synthesising biomolecule-drug-conjugates (e.g. antibody-drug-conjugates) using photocleavable moieties. The method comprises: (i) providing an immobilised photocleavable group-biomolecule conjugate； (ii) optionally contacting the immobilised photocleavable group-biomolecule conjugate with a chemical modification agent or activating agent to provide an immobilised photocleavable group-biomolecule conjugate that is chemically modified or activated at the biomolecule portion； (iii) contacting the immobilised photocleavable group-biomolecule conjugate of step (i) or the chemically modified or activated immobilised photocleavable group-biomolecule conjugate of step (ii) with a drug component to form an immobilised photocleavable group-biomolecule-drug-conjugate； and (iv) irradiating the immobilised photocleavable group-biomolecule-drug-conjugate of step (iii) with radiation thereby releasing the biomolecule-drug-conjugate.
