SARA LOUISE JENKINS,COLIN MARTIN MCKEE,DAVID JOHN EVANS,CHARLES IAN ROBERT JOHNSON
申请号：
GB201412134
公开号：
GB2528643A
申请日:
2014.07.08
申请国别(地区):
GB
年份:
2016
代理人:
摘要：
A solid phase method of synthesising biomolecule-drug-conjugates (e.g. antibody-drug-conjugates) using photocleavable moieties. The method comprises: (i) providing an immobilised photocleavable group-biomolecule conjugate (ii) optionally contacting the immobilised photocleavable group-biomolecule conjugate with a chemical modification agent or activating agent to provide an immobilised photocleavable group-biomolecule conjugate that is chemically modified or activated at the biomolecule portion (iii) contacting the immobilised photocleavable group-biomolecule conjugate of step (i) or the chemically modified or activated immobilised photocleavable group-biomolecule conjugate of step (ii) with a drug component to form an immobilised photocleavable group-biomolecule-drug-conjugate: and (iv) irradiating the immobilised photocleavable group-biomolecule-drug-conjugate of step (iii) with radiation thereby releasing the biomolecule-drug-conjugate.
