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CHEMICAL REAGENTS FOR THE ACTIVATION OF POLYSACCHARIDES IN THE PREPARATION OF CONJUGATE VACCINES
专利权人:
FINA BIOSOLUTIONS; LLC
发明人:
LEES, ANDREW
申请号:
CA2784144
公开号:
CA2784144C
申请日:
2010.12.17
申请国别(地区):
CA
年份:
2017
代理人:
摘要:
This invention provides novel reagents for cyanating polysaccharides in aqueous or part aqueous solutions so that they may be covalently linked to proteins either directly or through a spacer. These reagents include l-cyano-4-pyrrolidinopyridinium tetrafluoroborate (CPPT), 1-cyano-imidazole (1-CI), 1-cyanobenzotriazole (1-CBT), or 2-cyanopyridazine-3(2H)one (2-CPO), or a functional derivative or modification thereof. The examples illustrate the use of these reagents with a variety of polysaccharides and proteins showing that the methods are generally applicable.
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中国工程科技知识中心
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http://www.ckcest.cn/home/

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