Richard Goldsmith;Nan Chi Wan;Simon Mathieu;Bin;Irina Chuckowree;Janet Gunzner;Sally Oxenford;Georgette Castanedo;Adrian Folkes;Daniel P. Sutherlin;Steven Staben;Tim Heffron;Alan Olivero;Tracy Bayliss
发明人:
Tracy Bayliss,Irina Chuckowree,Adrian Folkes,Sally Oxenford,Nan Chi Wan,Georgette Castanedo,Richard Goldsmith,Janet Gunzner,Tim Heffron,Simon Mathieu,Alan Olivero,Steven Staben,Daniel P. Sutherlin,Bin
申请号：
US12978106
公开号：
US08383620B2
申请日:
2010.12.23
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Compounds of Formulas Ia-d where X is S or O, mor is a morpholine group, and R3 is a monocyclic heteroaryl group, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for modulating the activity of lipid kinases including PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula Ia-d for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
