CASTANEDO, GEORGETTE,DOTSON, JENNAFER,GOLDSMITH, RICHARD,GUNZNER, JANET,HEFFRON, TIM,MATHIEU, SIMON,OLIVERO, ALAN,STABEN, STEVEN,SUTHERLIN, DANIEL P.,TSUI, VICKIE,WANG, SHUMEI,ZHU, BING-YAN,BAYLISS, T
申请号：
CA2671845
公开号：
CA2671845C
申请日:
2007.12.05
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
Compounds of Formulas Ia-d where X is S or O, mor is a morpholine group, and R3 is a monocyclic heteroaryl group, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for modulating the activity of lipid kinases including PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula Ia-d for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed. Formula (Ic) and (Id).
