Irving H. Fox;Nobel T. Truong;Jason Brown;Csanad M. Varga;Catherine Scholz;Willow Diluzio;Vaithianathan Palaniappan
发明人:
Willow Diluzio,Nobel T. Truong,Csanad M. Varga,Vaithianathan Palaniappan,Jason Brown,Irving H. Fox,Catherine Scholz
申请号：
US14114832
公开号：
US20140377251A1
申请日:
2012.05.02
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Antibody formulations are described comprising a mixture of a non-reducing sugar, an anti-α4β7 antibody and at least one amino acid. The disclosed formulations have improved stability, reduced aggregate formation, and may retard degradation of the anti-α4β7 antibody therein or exhibit any combinations thereof. The present invention further provides a safe dosing regimen of these antibody formulations that is easy to follow, and which results in a therapeutically effective amount of the anti-α4β7 anti body in vivo.
