FOX, IRVING H,SCHOLZ, CATHERINE,VARGA, CSANAD M.,PALANIAPPAN, VAITHIANATHAN,BROWN, JASON,DILUZIO, WILLOW,TRUONG, NOBEL T.
申请号：
TW101115712
公开号：
TW201247223A
申请日:
2012.05.02
申请国别(地区):
TW
年份:
2012
代理人:
摘要：
Antibody formulations are described comprising a mixture of a non-reducing sugar, an anti- &agr； 4 &bgr； 7 antibody and at least one amino acid. The disclosed formulations have improved stability, reduced aggregate formation, and may retard degradation of the anti- &agr； 4 &bgr； 7 antibody therein or exhibit any combinations thereof. The present invention further provides a safe dosing regimen of these antibody formulations that is easy to follow, and which results in a therapeutically effective amount of the anti- &agr； 4 &bgr； 7 antibody in vivo.
