VENNERSTROM JONATHAN L.,JONATHAN L. VENNERSTROM,TANG YUANQING,YUANQING TANG,CHOLLET JACQUES,JACQUES CHOLLET,DONG YUXIANG,YUXIANG DONG,MATILE HUGUES,HUGUES MATILE,PADMANILAYAM MANIYAN,MANIYAN PADMANILA,MANIYAN PADMANILAYAM,PADMANILAYAM MANI
申请号：
PL369644
公开号：
PL227294B1
申请日:
2004.08.18
申请国别(地区):
PL
年份:
2017
代理人:
摘要：
A means and method for treating malaria, schistosomiasis, and cancer using a dispiro 1,2,4-trioxolane is described. The 1,2,4-trioxolanes include a spiroadamantane group on one side of the trioxolane group, and a spirocyclohexyl on the other side of the trioxolane group, whereby the spirocyclohexyl ring is substituted at the 4-position. In comparison to artemisinin semisynthetic derivatives, the compounds of this invention are structurally simple, easy to synthesize, non-toxic, and potent against malarial parasites.
