VENNERSTROM JONATHAN L.,JONATHAN L. VENNERSTROM,CHOLLET JACQUES,JACQUES CHOLLET,DONG YUXIANG,YUXIANG DONG,MATILE HUGUES,HUGUES MATILE,PADMANILAYAM MANIYAN,MANIYAN PADMANILAYAM,TANG YUANQING,YUANQING T,YUANQING TANG,TANG YUANQ
申请号：
PL367158
公开号：
PL226418B1
申请日:
2002.06.21
申请国别(地区):
PL
年份:
2017
代理人:
摘要：
A means and method for treating malaria using a spiro or dispiro 1,2,4-trioxolane is described. The preferred 1,2,4-trioxolanes include a spiroadamantane group on one side of the trioxolane group, and a spirocyclohexyl or spiropiperidyl ring on the other side of the trioxolane group, whereby the spirocyclohexyl ring is preferably functionalized or substituted at the 4-position or a spiropiperidyl ring that is functionalized or substituted at the nitrogen atom. In comparison to artemisinin semisynthetic derivatives, the compounds of this invention are structurally simple, easy to synthesize, non-toxic, and potent against malarial parasites.
