VENNERSTROM JONATHAN L. UNIV.OF NEBRASKA MED. C.,TANG YUANQUING UNIVERSITY OF NEBRASKA MEDIC.CEN.,DONG YUXIANG UNIVERSITY OF NEBRASKA MEDIC.CENTER,MATILE HUGHES PHARMA RESEARCH DEPARTMENT,CHARMAN WILL,Vennerstrom Jonathan L. Univ.of Nebraska Med. C.,Tang Yuanquing University of Nebraska Medic.Cen.,DONG
申请号：
SI200432293
公开号：
SI1514871T1
申请日:
2004.08.11
申请国别(地区):
SI
年份:
2016
代理人:
摘要：
A means and method for treating malaria, schistosomiasis, and cancer using a dispiro 1,2,4-trioxolane is described. The 1,2,4-trioxolanes include a spiroadamantane group on one side of the trioxolane group, and a spirocyclohexyl on the other side of the trioxolane group, whereby the spirocyclohexyl ring is substituted at the 4-position. In comparison to artemisinin semisynthetic derivatives, the compounds of this invention are structurally simple, easy to synthesize, non-toxic, and potent against malarial parasites.
