VENNERSTROM, JONATHAN L.,TANG, YUANQUING,DONG, YUXIANG,MATILE, HUGHES,CHARMAN, WILLIAM N.,CHOLLET, JAQUES,PADMANILAYAM, MANIYAN,YATENDRA, KUMAR,GYAN, CHAND YADAV
申请号：
PL04254821
公开号：
PL1514871T3
申请日:
2004.08.11
申请国别(地区):
PL
年份:
2016
代理人:
摘要：
A means and method for treating malaria, schistosomiasis, and cancer using a dispiro 1,2,4-trioxolane is described. The 1,2,4-trioxolanes include a spiroadamantane group on one side of the trioxolane group, and a spirocyclohexyl on the other side of the trioxolane group, whereby the spirocyclohexyl ring is substituted at the 4-position. In comparison to artemisinin semisynthetic derivatives, the compounds of this invention are structurally simple, easy to synthesize, non-toxic, and potent against malarial parasites.
