BIOMEDICAL RESEARCH MODELS, INC.;ORAL VACCINE TECHNOLOGIES, INC.
发明人:
YANG, KEJIAN,WHALEN, BARBARA J.,KISLAUSKIS, EDWARD H.,GUBERSKI, DENNIS L.
申请号：
CA2552004
公开号：
CA2552004C
申请日:
2005.01.07
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The invention relates to methods and reagents for immunizing animals to elicitspecific cellular and humoral immune-responses against specific antigens, suchas viral antigens, including HBsAg antigen. The invention provides methods ofusing specifically prepared immunogen in fresh or lyophilized liposome, properroutes of administration of the immunogen, proper doses of the immunogen, andspecific combinations of heterologous immunization including DNA priming inone administration route followed by liposome-mediated protein antigen boostin a different route to tailor the immune responses in respects of enhancingcell mediated immune response, cytokine secretion, humoral immune response,immune protection and selective skewing of T helper responses to be Th1, Th2,or a mixed or balanced Th response.
