BIOMEDICAL RESEARCH MODELS, INC.;ORAL VACCINE TECHNOLOGIES, INC.
发明人:
YANG, KEJIAN,WHALEN, BARBARA, J.,KISLAUSKIS, EDWARD, H.,GUBERSKI, DENNIS, L.
申请号：
DK05722399
公开号：
DK1706140T3
申请日:
2005.01.07
申请国别(地区):
DK
年份:
2012
代理人:
摘要：
The invention relates to methods and reagents for immunizing animals to elicit specific cellular and humoral immune-responses against specific antigens, such as viral antigens, including HBsAg antigen. The invention provides methods of using specifically prepared immunogen in fresh or lyophilized liposome, proper routes of administration of the immunogen, proper doses of the immunogen, and specific combinations of heterologous immunization including DNA priming in one administration route followed by liposome-mediated protein antigen boost in a different route to tailor the immune responses in respects of enhancing cell mediated immune response, cytokine secretion, humoral immune response, immune protection and selective skewing of T helper responses to be Th1, Th2, or a mixed or balanced Th response.
