The present invention relates to antigens and methods for the suppression of a hypersensitivity immune response via bystander suppression with an antigen unrelated to the allergen triggering a hypersensitivity immune response such as an allergic response in an individual. Treatment regiments covering the administering the unrelated antigen to the oral cavity (e.g. sublingual mucosa) combined with the administration of the unrelated antigen to either the respiratory tract, gastro-intestinal tract or skin in a simultaneous, contemporaneous, separate or sequential manner is provided.本發明關於經由抗原之旁路抑制以抑制超敏性免疫反應之抗原及方法,該抗原係與引發個體之超敏性免疫反應(諸如過敏反應)之過敏原無關。本發明提供包括投予該非相關抗原至口腔(例如舌下黏膜)與同時、併行、分開或依序之方式投予該非相關抗原至呼吸道、胃腸道或皮膚的組合之治療配方。