Disclosed is a patch for delivering a permeant through a biological membrane of a subject comprising: a) a matrix； b) at least one hydrophilic permeant disposed within the matrix, wherein at least a portion of the hydrophilic permeant can dissolve in biological moisture received from the subject； and c) at least one permeability enhancer disposed within the matrix, wherein the permeability enhancer is at least one pH control agent selected from the group consisting of: (I) pH control agents adapted to adjust at least a portion of contacted biological moisture to a pH level of from 2 to 6, and (II) pH control agents adapted to adjust at least a portion of contacted biological moisture to a basic non-physiological pH level.
