University of Pittsburgh - Of the Commonwealth System of Higher Education
发明人:
SONG LI,YIXIAN HUANG,XIAOLAN ZHANG,XIANG GAO
申请号：
US15703110
公开号：
US20180000957A1
申请日:
2017.09.13
申请国别(地区):
US
年份:
2018
代理人:
摘要：
A formulation includes a carrier agent formed by conjugating at least one biologically active hydrophobic compound with at least one hydrophilic compound, the at least one biologically active hydrophobic compound selected from the group of farnesylthiosalicylic acid and a derivative of farnesylthiosalicylic acid which is biologically active as an RAS antagonist, wherein a plurality of the carrier agents are adapted to assemble into a structure and the at least one biologically active hydrophobic compound is conjugated with the at least one hydrophilic compound via a linkage which is labile in vivo, and a biologically active compound associated with the carrier agent.
