SHAH, Kalpana,SMITH, Douglas H.,LA MOTTE-MOHS, Ross,JOHNSON, Leslie S.,MOORE, Paul A.,BONVINI, Ezio,KOENIG, Scott
申请号：
PE2018000138
公开号：
PE20181151A1
申请日:
2016.07.28
申请国别(地区):
PE
年份:
2018
代理人:
摘要：
The invention aims at some anti-virus antibodies of PD-1 type that can be added to PD-1 single machine and PD-1 human at the same time: mAb 1 type PD-1, mAb 2 type PD-1, mAb 3 type PD-1, mAb 4 type PD-1, mAb 5 type PD-1 and MAb 6 type PD-1,MAb 7 of PD-1, mAb 8 of PD-1, mAb 9 of PD-1, mAb 10 of PD-1, mAb 11 of PD-1, mAb 12 of PD-1, mAb 13 of PD-1, rnab 14 of PD-1 or mAb 15 of PD-1, and humanitarian or chemical versions of these antibodies. The invention also belongs to the molecule combined to PD-1 type, including the fragment of the anti retroviral antibody of PD-1 type combined to PD-1 type, immunococcus, and the Bichemical molecule including diaphragm, bit, dioxygen antibody, etc.These include (1) the fragment linked to PD-1, and (2) a domain that can connect a vertex on a molecule, which involves regulating immune control points on the surface of immune cells. The present invention also belongs to the method of stimulating immune response with molecules attached to PD-1, so the angle pair method is used to detect PD-1.La presente invencion se dirige a anticuerpos anti PD-1 seleccionados capaces de unirse tanto a PD-1 de mono cynomolgus y a PD-1 de humano: mAb 1 de PD-1, mAb 2 de PD-1, mAb 3 de PD-1, mAb 4 de PD-1, mAb 5 de PD- 1, mAb 6 de PD- 1 , mAb 7 de PD-1, mAb 8 de PD-1, mAb 9 de PD-1, mAb 10 de PD-1, mAb 11 de PD-1, mAb 12 de PD-1, mAb 13 de PD-1, rnAb 14 de PD-1 o mAb 15 de PD-1, y a versiones humanizadas o quimericas de tales anticuerpos. La invencion pertenece de manera adicional a moleculas de union a PD-1 que comprenden fragmentos de union a PD-1 de tales anticuerpos anti -PD-1, inmunoconjugados, y a moleculas biespecificas, que incluyen diacuerpos, BiTE, anticuerpos biespecificos, etc., que comprenden (i) tales fragmentos de union a PD-1, y (ii) un dominio capaz de unir un epitopo de una molecula involucrada en regular un punto de control inmune presente en la superficie de celulas inmunes. La presente invencion tambien pertenece a metodos para utiliz
