JOHNSON LESLIE S.,BONVINI EZIO,MOORE PAUL A.,SHAH KALPANA,LA MOTTE-MOHS ROSS,SMITH DOUGLAS H.,KOENIG SCOTT,JOHNSON LESLIE S,MOORE PAUL A,SMITH DOUGLAS H,KO
申请号：
CL2017003132
公开号：
CL2017003132A1
申请日:
2017.12.07
申请国别(地区):
CL
年份:
2018
代理人:
摘要：
<； p >； The present Invention is directed to the Antibody.S anti lag-3, MAB 1 lag-3, MAB 2 lag-3 MAB lag-3, 4, 5 and 6 lag3 MAB MAB of lag-3, and Humanized and quim u00c9ricas versions of such Antibodies.The Invention belongs to the Union in addition to Molecules of lag-3 Fragments comprising the Union of lag-3 lag-3 such anti-a Antibodies, Immunoconjugates and biespec u00cdficas molecules.Diacuerpos Antibodies including, Bites, biespecificos, etc.(i) comprising such Fragments of Union lag-3,And (ii) a domain capable of Uniting a ep u00cdtopo a MOL u00c9CULA involved in regulating an immune Control Point on the surface of immune cells.The present Invention also belongs to methods for Detecting lag-3, and also methods to use molecules that Bind lag-3 to stimulate immune responses. <； / p >；La invención está relacionada con anticuerpos que se unen a LAG-3 humano y de mono Cynomolgus.
