SHAH, Kalpana,SMITH, Douglas H.,LA MOTTE-MOHS, Ross,JOHNSON, Leslie S.,MOORE, Paul A.,BONVINI, Ezio,KOENIG, Scott
申请号：
PE0001382018
公开号：
PE11512018A1
申请日:
2016.07.28
申请国别(地区):
PE
年份:
2018
代理人:
摘要：
The present Invention relates to Antibodies against pd-1 selected capable of binding to pd-1 cynomolgus Monkey and Human pd-1 MAB 1: pd-1 MAB 2 pd-1 MAB PD - 1, 3, 4 of pd-1 MAB.MAB 5 pd-1 MAB 6 pd-1 MAB 7 pd-1 MAB 8 pd-1 MAB 9 pd-1 MAB 10 pd-1 MAB 11 pd-1 MAB 12 pd-1 MAB 13 pd-1, rnab pd-1 MAB 14 or 15 PD - 1Chimeric and Humanized or versions of such Antibodies.The Invention belongs to an additional Binding to pd-1 molecules that include Fragments Binding to pd-1 such anti - PD - 1 Antibodies, Immunoconjugates and biespecificas molecules.Diacuerpos Antibodies including, BITE, biespecificos, etc.(i) comprising such Fragments Binding to pd-1.And (ii) a domain can bind an epitope of a Molecule involved in regulating immune control of a Point on the surface of immune cells.The present Invention also belongs to methods for using molecules that bind to pd-1 to stimulate immune responses, as well as to methods for Detecting pd-1.La presente invencion se dirige a anticuerpos anti PD-1 seleccionados capaces de unirse tanto a PD-1 de mono cynomolgus y a PD-1 de humano: mAb 1 de PD-1, mAb 2 de PD-1, mAb 3 de PD-1, mAb 4 de PD-1, mAb 5 de PD- 1, mAb 6 de PD- 1 , mAb 7 de PD-1, mAb 8 de PD-1, mAb 9 de PD-1, mAb 10 de PD-1, mAb 11 de PD-1, mAb 12 de PD-1, mAb 13 de PD-1, rnAb 14 de PD-1 o mAb 15 de PD-1, y a versiones humanizadas o quimericas de tales anticuerpos. La invencion pertenece de manera adicional a moleculas de union a PD-1 que comprenden fragmentos de union a PD-1 de tales anticuerpos anti -PD-1, inmunoconjugados, y a moleculas biespecificas, que incluyen diacuerpos, BiTE, anticuerpos biespecificos, etc., que comprenden (i) tales fragmentos de union a PD-1, y (ii) un dominio capaz de unir un epitopo de una molecula involucrada en regular un punto de control inmune presente en la superficie de celulas inmunes. La presente invencion tambien pertenece a metodos para utilizar moleculas que se unen a PD-1 para estimular respuestas inmunes, asi corno a metodos para detectar
