SHAH KALPANA,SMITH DOUGLAS H,LA MOTTE MOHS ROSS,JOHNSON LESLIE S,MOORE PAUL A,BONVINI EZIO,KOENIG SCOTT
申请号：
IN201817003338
公开号：
IN201817003338A
申请日:
2018.01.29
申请国别(地区):
IN
年份:
2018
代理人:
摘要：
The present invention is directed to selected anti PD 1 antibodies capable of binding to both cynomolgus monkey PD 1 and to human PD 1 : PD 1 mAb 1 PD 1 mAb 2 PD 1 mAb 3 PD 1 mAb 4 PD 1 mAb 5 PD 1 mAb 6 PD 1 mAb 7 PD 1 mAb 8 PD 1 mAb 9 PD 1 mAb 10 PD 1 mAb 11 PD 1 mAb 12 PD 1 mAb 13 PD 1 mAb 14 or PD 1 mAb 15 and to humanized and chimeric versions of such antibodies. The invention additionally pertains to PD 1 binding molecules that comprise PD 1 binding fragments of such anti PD 1 antibodies immunocongugates and to bispecific molecules including diabodies BiTEs bispecific antibodies etc. that comprise (i) such PD 1 binding fragments and (ii) a domain capable of binding an epitope of a molecule involved in regulating an immune check point present on the surface of an immune cells. The present invention also pertains to methods of using molecules that bind PD 1 for stimulating immune responses as well as methods of detecting PD 1.
