噁二唑暫時受體電位通道抑制劑农业专利-农业学术服务平台

发明人:: TERRETT, JACK ALEXANDER,泰瑞特　杰克　亚历山大,泰瑞特　傑克　亞歷山大,CHEN, HUIFEN,陈　慧芬,陳　慧芬,CONSTANTINEAU-FORGET, LEA,康斯坦汀奥　福杰　黎亚,康斯坦汀奧　福杰　黎亞,LAROUCHE-GAUTHIER, ROBIN,拉罗杰　高提亚　罗宾,拉羅傑　高提亞　羅賓,LEPISSIER, LUCE,雷皮西尔　路洁,雷皮西爾　路潔

摘要：: The invention relates to compounds of formula I:and pharmaceutically acceptable salts thereof wherein A, X, R1, R4and n are as defined herein. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.本發明係關於式I化合物：及其醫藥學上可接受之鹽，其中A、X、R1、R4及n如本文所定義。此外，本發明係關於式I化合物之製造方法及使用方法以及含有此類化合物之醫藥組合物。該等化合物可適用於治療由TRPA1介導之疾病及病狀，諸如疼痛。