The present invention relates to pharmaceutical compounds of the Formula (I), or a pharmaceutically acceptable salt or composition thereof, and methods of their use for the treatment of pain, respiratory conditions, as well as inhibiting the Transient Receptor Potential A1 ion channel (TRPA1).本發明係關於式(I)之醫藥化合物或其醫藥上可接受之鹽或組合物,及其用於治療疼痛、呼吸病狀以及抑制瞬時受體電位A1離子通道(TRPA1)之方法。