經取代之磺醯胺化合物农业专利-农业学术服务平台

发明人:: BROTHERTON-PLEISS, CHRISTINE E.,巴松顿　布列斯　克里斯汀Ｅ,巴松頓　布列斯　克里斯汀Ｅ,CHEN, HUIFEN,陈慧芬,陳慧芬,CHEN, SHAOQING,陈晓菁,陳曉菁,CHEN, ZHI,陈齐,陳齊,ERICKSON, SHAWN DAVID,艾瑞克森　尙　大卫,艾瑞克森　尙　大衛,ESTRADA, ANTHONY,艾斯达　安东尼,艾斯達　安東尼,KIM,,巴松顿布列斯克里斯汀E,巴松頓布列斯克里斯汀E,艾瑞克森尙大卫,艾瑞克森尙大衛,艾斯达安东尼,艾斯達安東尼

摘要：: The invention is concerned with the compounds of formula (I): and salts thereof, wherein X, Y, Z, R1, R2, R3, R3’, R4, R5 and R6 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of Formula (I) as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.本發明係關於式(I)化合物：及其鹽，其中X、Y、Z、R1、R2、R3、R3’、R4、R5及R6係如詳細說明及申請專利範圍中所定義。此外，本發明係關於製造及使用該等式(I)化合物以及含有該等化合物之醫藥組合物之方法。該等化合物可用於治療由TRPA1介導之疾病及病況，例如疼痛。