The invention is concerned with the compounds of formula I: and salts thereof and other compounds of formulas II-IX as disclosed herein. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formulas I-IX as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain or asthma.本發明係關於式I化合物:及其鹽及如本文中所揭示之其他式II-IX之化合物。此外,本發明係關於製造式I-IX之化合物的方法,及使用式I-IX之化合物的方法,以及含有該等化合物之醫藥組合物。該等化合物可用於治療由TRPA1介導之疾病和病狀,諸如疼痛或哮喘。