萘基乙酸农业专利-农业专业知识服务系统

发明人:: FIROOZNIA, FARIBORZ,菲罗兹尼亚　法罗伯兹,菲羅茲尼亞　法羅伯茲,GILLESPIE, PAUL,吉尔斯比　保罗,吉爾斯比　保羅,LIN, TAI-AN,林泰安,MERTZ, ERIC,马提兹　艾瑞克,馬提茲　艾瑞克,SIDDURI, ACHYUTHARAO,西度利　亚修沙罗,西度利　亞修沙羅,SO, SUNG-SAU,苏崇修,蘇崇修,TAN, JENNY,谭　珍妮,譚　,菲罗兹尼亚法罗伯兹,菲羅茲尼亞法羅伯茲,吉尔斯比保罗,吉爾斯比保羅,马提兹艾瑞克,馬提茲艾瑞克,西度利亚修沙罗,西度利亞修沙羅,谭珍妮,譚

摘要：: The invention is concerned with the compounds of formula I:and pharmaceutically acceptable salts and esters thereof, wherein X, Q, and R1-R6are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists or partial agonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.本發明係關於式I化合物：及其藥學上可接受之鹽類與酯類，其中X、Q及R1-R6係被定義於詳細說明文與請求項中。此外，本發明係關於製造與使用式I化合物之方法，以及含有此種化合物之醫藥組合物。式I化合物係為對CRTH2受體之拮抗劑或部份催動劑，且可用於治療與該受體有關聯之疾病與病症，譬如氣喘。