萘乙酸农业专利-农业专业知识服务系统

发明人:: CHEN, LI,陈力,陳力,FIROOZNIA, FARIBORZ,菲罗兹尼亚　法罗伯兹,菲羅茲尼亞　法羅伯茲,GILLESPIE, PAUL,吉尔斯比　保罗,吉爾斯比　保羅,HE, YUN,席元,LIN, TAI-AN,林泰安,MERTZ, ERIC,马提兹　艾瑞克,馬提茲　艾瑞克,SO, SUNG-SAU,苏崇修,蘇崇修,YUN, HONGYING,貟红英,貟紅英,ZHANG,,菲罗兹尼亚法罗伯兹,菲羅茲尼亞法羅伯茲,吉尔斯比保罗,吉爾斯比保羅,马提兹艾瑞克,馬提茲艾瑞克

摘要：: The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein W, X, Y, and R1-R7 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists or partial agonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.本發明係關於式I化合物：；I；及其藥學上可接受之鹽類與酯類，其中W、X、Y及R1-R7係被定義於詳細說明文與請求項中。此外，本發明係關於製造與使用式I化合物之方法，以及含有此種化合物之醫藥組合物。式I化合物係為對CRTH2受體之拮抗劑或部份催動劑，且可用於治療與該受體有關聯之疾病與病症，譬如氣喘。