The present invention relates to a novel process for producing transmucosal pharmaceutical formulations and to formulations thus obtained. The process relates to the preparation of grains comprising a thermolabile substance as active ingredient, and consists in dissolving said substance in a ternary mixture composed of two amphiphilic binders, the melting point of which is between 40 and 60°C, and of an aqueous solvent such as, in particular, water, an aqueous-alcoholic solution or a water-soluble solvent. The grains thus obtained comprise a thermolabile active substance, two amphiphilic binders and an inert carrier. Use in obtaining translingual tablets wherein the thermolabile active substance is adrenalin.La présente invention concerne un nouveau procédé de fabrication de formulations pharmaceutiques transmuqueuses et formulations ainsi obtenues. Le procédé concerne la préparation de grains comportant comme principe actif une substance thermolabile et consiste à dissoudre ladite substance dans un mélange ternaire composé de deux liants amphiphiles dont la température de fusion est comprise entre 40 et 60°C et dun solvant aqueux tel que, notamment, leau, une solution hydroalcoolique ou un solvant hydrosoluble. Les grains ainsi obtenus comprennent une substance active thermolabile, deux liants amphiphiles et un support inerte. Application à lobtention de comprimés translinguaux où la substance active thermolabile est ladrénaline.
