The present invention relates to a novel process for the manufacture of transmucosal pharmaceutical formulations and formulations thus obtained. The process relates to the preparation of grains comprising as active principle a thermolabile substance and consists in dissolving said substance in a ternary mixture composed of two amphiphilic binders whose melting point is between 40 and 60 ° C. and an aqueous solvent such as in particular, water, a hydroalcoholic solution or a water-soluble solvent. The grains thus obtained comprise a thermolabile active substance, two amphiphilic binders and an inert support. Application to obtaining translingual tablets where the thermolabile active substance is adrenaline. La présente invention concerne un nouveau procédé de fabrication de formulations pharmaceutiques transmuqueuses et formulations ainsi obtenues. Le procédé concerne la préparation de grains comportant comme principe actif une substance thermolabile et consiste à dissoudre ladite substance dans un mélange ternaire composé de deux liants amphiphiles dont la température de fusion est comprise entre 40 et 60°C et d'un solvant aqueux tel que, notamment, l'eau, une solution hydroalcoolique ou un solvant hydrosoluble. Les grains ainsi obtenus comprennent une substance active thermolabile, deux liants amphiphiles et un support inerte. Application à l'obtention de comprimés translinguaux où la substance active thermolabile est l'adrénaline.
