JUNG, Young Hee;박철현;김원정;HANMI PHARMACEUTICAL CO., LTD.;정영희;KIM, Nam Du;K;김남두;CHANG, Young Kil;한미약품 주식회사;KOREA HEALTH INDUSTRY DEVELOPMENT INSTITUTE(KHIDI);한국보건산업진흥원;PARK, Chul Hyun;KIM, Won Jeoung;장영길
发明人:
PARK, Chul Hyun,박철현,KIM, Won Jeoung,김원정,JUNG, Young Hee,정영희,KIM, Nam Du,김남두,CHANG, Young Kil,장영길,KIM, Maeng Sup,김맹섭
申请号：
KRKR2012/005193
公开号：
WO2013/015535A2
申请日:
2012.06.29
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
The present invention relates to a compound selected from the group consisting of a compound represented by chemical formula 1 for inhibiting the activity of diacylglycerol 0-acyltransferase type 1, and pharmaceutically acceptable salts thereof, and to a pharmaceutical composition including same as an active ingredient. The compound of the present invention may be used as an effective therapeutic agent for treating, without side effects, diseases such as obesity, type II diabetes, dyslipidemia, metabolic syndrome, etc. induced by the activity of DGAT1. In chemical formula 1, A, B, X and R5-7 are the same as those defined in the present specification.La présente invention porte sur un composé qui est choisi dans le groupe constitué par les composés représentés par la formule chimique (1) et qui permet d'inhiber l'activité de la diacylglycérol O-acyltransférase de type 1, et sur les sels de qualité pharmaceutique de celui-ci, et sur une composition pharmaceutique le comprenant comme principe actif. Le composé de la présente invention peut être utilisé comme agent thérapeutique efficace pour le traitement, sans effets secondaires, de maladies telles que l'obésité, le diabète de type II, la dyslipidémie, le syndrome métabolique, etc. provoquées par l'activité de la DGAT1. Dans la formule chimique (1), A, B, X et R5-7 sont les mêmes que ceux définis dans la description.본 발명은 디아실글리세롤 0-아실전이효소 1형의 활성을 억제하는 하기 화학식 1의 화합물, 및 이의 약학적으로 허용 가능한 염으로 이루어진 군으로부터 선택된 화합물 및 이를 유효성분으로 함유하는 약학 조성물에 관한 것으로, 본 발명의 화합물은 DGAT1의 활성에 의해 유발되는 비만, 제2형 당뇨병, 이상지질혈증, 대사증후군 등의 질환에 대한 부작용 없이 효과적인 치료제로서 활용될 수 있다. 상기 [화학식 1]에서, A, B, X 및 R5~7은 본원 명세서에서 정의한 바와 같다.
