VACCARO, Wayne,CHEN, Zhong,DODD, Dharmpal S.,HUYNH, Tram N.,LIN, James,LIU, Chunjian,MUSSARI, Christopher P.,TOKARSKI, John S.,TORTOLANI, David R.,WROBLESKI, Stephen T.
申请号:
PH12013501329
公开号:
PH12013501329B1
申请日:
2013.06.21
申请国别(地区):
PH
年份:
2014
代理人:
摘要:
Compounds having the formula (I), and enantiomers, and diastereomers, pharmaceutically-acceptable salts thereof, are useful as kinase modulators, including MK2 modulation, wherein one of E and F is a nitrogen atom and the other of E and F is a carbon atom, Z is N or CR3, and R1, R2, R3, X and Y are as defined herein.