Compounds having the formula (1), and enantiomers, and diastereomers, pharmaceutically-acceptable salts, thereof, are usefuil as kinase modulators, including MK2 modulation, wherein one of E and F is a nitrogen atom and the other of E and F is a carbon atom, Z is N or CR<；SUB>；3<；/SUB>；, and R<；SUB>；1<；/SUB>；, R<；SUB>；2<；/SUB>；, R<；SUB>；3<；/SUB>；, X and Y are as defined herein.
