Compounds having the formula (1), and enantiomers, and diastereomers, pharmaceutically-acceptable salts, thereof, are usefuil as kinase modulators, including MK2 modulation, wherein one of E and F is a nitrogen atom and the other of E and F is a carbon atom, Z is N or CR<;SUB>;3<;/SUB>;, and R<;SUB>;1<;/SUB>;, R<;SUB>;2<;/SUB>;, R<;SUB>;3<;/SUB>;, X and Y are as defined herein.