NOVEL CRYSTALLINE FORM OF BIS [(E)-7- [4-(4-FLUOROPHENYL)-6-ISOPROPYL-2- [ METHYL(METHYLSULFONYL)AMINO]PYRIMIDIN-5-YL](3R,5S)-3,5-DIHYDROXYHEPT-6-ENOIC ACID] CALCIUM SALT,AND RELEVANT MANUFACTURE PROCESS, PHARMACEUTICAL COMPOSITION, AND USE农业专利-农业学术服务平台

发明人:: BOOTH, REBECCA JANE,罗贝卡琴布斯,羅貝卡琴布斯,CRABB, JEFFREY NORMAN,捷夫列诺曼克拉波,捷夫列諾曼克拉波,JONES, DAVID WYN CALVERT,大卫外恩卡维特琼恩,大衛外恩卡維特瓊恩,CITTERN, PETER ANTHONY,彼得安东尼席特恩,彼得安東尼席特恩,HORBURY, JOHN,约翰哈宝瑞,約

摘要：: Two polymorphic forms of bis[(E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6-enoic acid]calcium salt, processes for making them and their use as HMG Co-A reductase inhibitors are described.本發明描述雙[(E)-7-[4-(4-氟苯基)-6-異丙基-2-[甲基(甲磺醯基)胺基]嘧啶-5-基](3R,5S)-3,5-二羥基-庚-6-烯酸]鈣鹽之兩種多晶型式、其製備方法以及其用作HMG CoA還原酶抑制劑之用途。