The present invention provides novel formulations of isobutyric acid (2R,3R,4R,5R)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-4-fluoro-2-isobutyryloxymethyl-4-methyl-tetrahydro-furan-3-yl ester) and hydroxypropylcellulose that provide high bulk density, low particle size better suited for improved compression and flow, good compression, and fast dissolution profiles.本發明係關於一種異丁酸(2R,3R,4R,5R)-5-(4-胺基-2-側氧基-2H-嘧啶-1-基)-4-氟-2-異丁醯氧基甲基-4-甲基-四氫-呋喃-3-基酯及羥基丙基纖維素之新穎調配物,其提供高體積密度、更適合改良壓縮及流動之低粒度、良好的壓縮性以及快速溶解曲線。(無元件符號說明)
