New (poly)aminoalkylaminoalkylamide, alkyl-urea, or alkyl-sulfonamide derivatives of epipodophyllotoxin, a process for preparing them, and application thereof in therapy as anticancer agents
Imbert, Thierry,Guminski, Yves,Barret, Jean-Marc,Kruczynski, Anna
申请号:
AU2009284086
公开号:
AU2009284086B2
申请日:
2009.08.19
申请国别(地区):
AU
年份:
2014
代理人:
摘要:
The present invention relates to new derivatives of epipodophyllotoxin 4-substituted with an optionally substituted (poly)aminoalkylaminoalkylamidc, or alkyl-urea or alkyl- sulfonamide chain, a process for preparing them and their use as a medicine as an anticancer agent. Formula (1) wherein: - R represents hydrogen or C