Xiaopeng LI,Chao TIAN,Jingshu ZHAO,Jiajia LIU,Hua ZHOU,Chunyang SUN
申请号：
US16620738
公开号：
US20200149067A1
申请日:
2018.06.15
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Provided are a recombinant herpes simplex virus, a preparation method and use thereof. The recombinant herpes simplex virus comprises a vector and foreign genes encoding at least two cytokines, wherein the vector is a herpes simplex virus with genes encoding ICP34.5 and ICP47 deleted, and optionally with at least one of genes encoding ICP6, TK and UNG deleted, and the insertion site/sites of the foreign genes is in at least one of the positions where the genes encoding ICP34.5, ICP47, ICP6, TK and UNG are deleted in the vector.
