KARP, GARY MITCHELL,HWANG, SEONGWOO,CHEN, GUANGMING,ALMSTEAD, NEIL GREGORY,MOON, YOUNG-CHOON
申请号：
ES04759404
公开号：
ES2528195T3
申请日:
2004.04.09
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound of formula (I): ** Formula ** wherein: Z is substituted aryl other than 4-cyanophenyl, substituted or unsubstituted heteroaryl selected from triazolyl, tetrazolyl, oxadiazolyl, furyl, benzofuranyl, thiophenyl, benzothiophenyl, benzoisoxazolyl, benzoisothiazolyl , quinolinyl, pyrrolyl, indolyl, oxazolyl, benzoxazolyl, benzimidazolyl, benzothiazolyl, isoxazolyl, pyrazolyl, isothiazolyl, pyridazinyl, pyrazinyl, triazinyl, cinnolinyl, phthalazinyl, quinazolinyl, benzoquinazolinilo or acridinyl, substituted cycloalkyl or unsubstituted alkyl, substituted or unsubstituted heterocycle substituted or unsubstituted selected from morpholinyl, pyrrolidinonyl, pyrrolidinyl, hydantoinyl, valerolactamyl, oxyranyl, oxetanyl, tetrahydrofuranoyl, tetrahydropyranyl, tetrahydrothiophenyl or tetrahydrothiopyranyl, substituted or unsubstituted arylalkyl； or Z is p-tolyl； (4-chloromethyl-phenyl)； (4-ethyl-phenyl)； o-tolyl； (3-methyl-thiophene-2-yl)； (4-tert-butyl-phenyl)； m-tolyl； (2,5-dimethyl-furan-3-yl)； (4-pyrrol-1-yl-phenyl)； (4-nitro-phenyl)； (4-isobutyl-phenyl)； [3- (2-Chloro-6-fluoro-phenyl) -5-methyl-isoxazol-4-yl]； or [3- (2-Chloro-phenyl) -5-methyl-isoxazol-4-yl]； R1 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or - (CH2CH2O) nR6； R2, R3, R4, and R5 are independently hydrogen, alkoxy or halogen； R6 is hydrogen or alkyl； n is an integer from 1 to 7； and the term "substituted" means a group substituted by one to four substituents, selected from halo, trifluoromethyl, trifluoromethoxy, hydroxy, alkoxy, cycloalkyloxy, heterocyclooxy, oxo, alkanoyl, alkylcarbonyl, cycloalkyl, aryl, aryloxy, aralkyl, alkanoyloxy, cyano, azido, amino, alkylamino, arylamino, aralkylamino, cycloalkylamino, heterocycloamino, or mono and disubstituted amino in which the one or two substituents in the amino group are selected from
