GRIFFIOEN, GERARD,NETTEKOVEN, MATTHIAS,PRINCEN, KATRIEN,RATNI, HASANE,VIFIAN, WALTER
申请号：
ES12737238
公开号：
ES2540956T3
申请日:
2012.06.29
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound of the formula IA ** Formula ** wherein R1 is hydrogen； lower alkyl； lower alkyl substituted with halogen； halogen； lower alkoxy； lower alkoxy substituted with halogen； or cyano； R2 is hydrogen； lower alkyl； lower alkyl substituted with halogen； halogen； lower alkoxy； or is halogen substituted lower alkoxy； C1 is phenyl； benzo [1,3] dioxol； pyridin-2-yl； pyridin-3-yl； pyridin-4-yl； thiophene-2-yl； pyrazin-2-yl； pyridazin-4-yl； pyrimidin-5-yl； piperidin-1-yl； tetrahydro-2H-pyran-4-yl； or cycloalkyl； C2 is phenyl； benzo [1,3] dioxol； pyridin-2-yl； pyridin-3-yl； pyridin-4-yl； thiophene-2-yl； pyrazin-2-yl； pyridazin-4-yl； pyrimidin-5-yl； piperidin-1-yl； tetrahydro-2H-pyran-4-yl； or cycloalkyl； X is -CH2-； -CH2-CHR-； -CH2-CH2-CH2-； -CH2C (O) -； -CHR'-CH2-； CH2 C； or CH2； R is hydrogen； hydroxyl； halogen or lower alkyl； R 'is lower alkyl； n is 1 or 2； if n is 2, R1 can be independently selected from each other； o is 1 or 2； if or is 2, R2 can be independently selected from each other； or a pharmaceutically active salt thereof； or a stereoisomeric form, including a single diastereoisomer or enantiomer of the compound of the formula IA in addition to a racemic or non-racemic mixture thereof, wherein, the term "lower alkyl" indicates a saturated straight or branched chain group containing 1 to 7 carbon atoms； the term "lower alkoxy" indicates a group in which the alkyl residue is as defined above and which is linked by an oxygen atom； the term "halogen substituted lower alkyl" indicates an alkyl group as defined above, wherein at least one hydrogen atom is replaced by halogen； The term "halogen substituted lower alkoxy" indicates an alkoxy group as defined above, wherein at least one hydrogen atom is replaced by halogen.Un compuesto de la fórmula IA**Fórmula** en donde R1 es hidrógeno； alquilo inferior； alquilo inferior sustituido con halógeno； halógeno； alcoxi inferior； alcoxi inferior sustituido con halógeno； o ciano； R2 es hidrógeno； alquilo inferior； alquilo i
