INTERVET INTERNATIONAL B. V.;MERCK SHARP & DOHME B. V.
发明人:
MIDDELBEEK, HANS ALMER,SMIT, JOZEFUS A. C.,VERHEEZEN, JACOBUS JOHANNES ADRIANA MARIA
申请号：
TW99113079
公开号：
TWI471127B
申请日:
2010.04.26
申请国别(地区):
TW
年份:
2015
代理人:
摘要：
The present invention pertains to a process for the preparation of a fast-disintegrating tablet (30) containing a medicinal substance, comprising the steps of providing a fluid formulation comprising the medicinal substance, providing a solid element (100) having formed therein at least one cavity, (101) cooling the solid element (100) to a temperature below a freezing temperature of the formulation, filling the cavity with the fluid formulation, solidifying the formulation while present in the cavity (101) to form a solid pellet comprising the medicinal substance without actively shaping the entire surface of the pellet, taking the pellet out of the cavity and drying the pellet in a vacuum to obtain the tablet. The invention also pertains to a system for performing such a process and a package containing the resulting tablet.
