HAHN, Sei Kwang,한세광,KONG, Won Ho,공원호,PARK, Kitae,박기태
申请号：
KRKR2013/008834
公开号：
WO2014/058179A2
申请日:
2013.10.02
申请国别(地区):
WO
年份:
2014
代理人:
摘要：
The present invention relates to low-density lipoprotein analogue cationic lipid nanoparticles in solid form, to a composition comprising same for liver-targeted delivery of a composition for diagnosing and/or treating liver diseases, and to a method for targeting the liver using an active ingredient, wherein the low-density lipoprotein analogue cationic lipid nanoparticles in solid form target liver cells including parenchyma cells and non-parenchyma cells which form the liver tissue.La présente invention concerne des nanoparticules lipidiques cationiques danalogue de lipoprotéine basse densité sous forme solide, une composition les comprenant pour ladministration ciblée sur le foie dune composition de diagnostic et/ou de traitement de maladies hépatiques et un procédé pour cibler le foie en utilisant un ingrédient actif, les nanoparticules lipidiques cationiques danalogue de lipoprotéine basse densité sous forme solide ciblant des cellules hépatiques, notamment les cellules parenchymateuses et les cellules non parenchymateuses qui forment le tissu hépatique.간 조직을 구성하는 실질세포(parenchyma cell) 및 비 실질세포(non-parenchyma cell)를 포함한 간세포를 표적으로 하는 저밀도 지단백 유사 양이온성 고형 지질 나노입자와 이를 포함하는 간질환 진단 및/또는 치료용 조성물의 간 표적 전달용 조성물 및 활성성분의 간 표적화방법에 관한 것이다.
