Bispecific binding molecules for anti-angiogenesis therapy

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专利权人:

BOEHRINGER INGELHEIM INTERNATIONAL GMBH

发明人:

BORGES ERIC,GSCHWIND ANDREAS,BOUCNEAU JOACHIM,DE TAVERNIER EVELYN,KOLKMAN JOOST,MERCHIERS PASCAL,VAN HOORICK DIANE

申请号：

NZ59895610

公开号：

NZ598956A

申请日:

2010.10.01

申请国别(地区):

NZ

年份:

2014

代理人:

摘要：

Disclosed is a binding molecule comprising a D114-binding component and a VEGF-binding component, wherein said Dll4-binding component is a VHH having an amino acid sequence selected from sequences shown in SEQ ID NOs: 34 and 35 and said VEGF-binding component is a VHH having an amino acid sequence selected from sequences shown in SEQ ID NOs: 42 - 44. The disclosed binding molecule has the following CDR regions according to SYAMA, AIRWSGGTAYYADSVKG, WGQGTLVTVSS, SYSMG, AISXGGXXYDAVSLXG and SRAYGSSRLRLADTYDY

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