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Nucleic acid compounds for inhibiting VEGF family gene expression and uses thereof
专利权人:
发明人:
申请号:
EP12153919.1
公开号:
EP2468864A1
申请日:
2008.02.28
申请国别(地区):
EP
年份:
2012
代理人:
摘要:
The present disclosure provides meroduplex ribonucleic acid molecules (mdRNA) capable of decreasing or silencing one or more VEGF family gene expression. An mdRNA of this disclosure comprises at least three strands that combine to form at least two non-overlapping double-stranded regions separated by a nick or gap wherein one strand is complementary to one or more VEGF family mRNA. In addition, the meroduplex may have at least one uridine substituted with a 5-methyluridine and optionally other modifications or combinations thereof. Also provided are methods of decreasing expression of one or more VEGF family gene in a cell or in a subject to treat one or more VEGF family-related disease.
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