Use of paulone derivatives for the manufacture of drugs for the treatment of mucoviscidosis and diseases linked to a defect in the targeting of proteins in cells
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS);UNIVERSITE DE POITIERS
发明人:
BECQ, FREDERIC,MEIJER, LAURENT,KUNICK, CONRAD
申请号：
ES05809765
公开号：
ES2378829T3
申请日:
2005.10.14
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
Use of paulone derivatives to manufacture drugs for the treatment of mucoviscidosis, these derivatives responding to the general formula (II): in which - X represents a group C = O, CS-CH3, CS, -C-NHOH； - R5 represents a hydrogen atom or a C1 to C5 alkyl group； - R12 represents a hydrogen atom, or a group -C-CO2- (CH3) 3； - R1 to R4, R7 to R11 identical or different, represent a hydrogen atom, halogen (F, Cl, Br, I), a hydroxy group, alkylene hydroxy, alkynoalkylenehydroxy, alcinohydroxycyclohexyl, alkyl, alkoxy, alkylene alkoxy, alkylene, these radicals being straight or branched chain, in C1 to C18, the group alkylene being saturated or unsaturated； said chain being substituted, if necessary, by one or more hydroxy or amino groups； a trifluoromethyl group； a -COM group； -COOM； or -CH2COOM (with M representing a hydrogen atom, a C1 to C18 alkyl group, straight or branched chain, substituted, if necessary, by one or more hydroxy and / or amino groups)； a nitrous group； or a cyano group； and the physiologically acceptable salts of these derivatives.Uso de derivados de paulonas para fabricar medicamentos para el tratamiento de la mucoviscidosis, estos derivados respondiendo a la fórmula general (II): en la que- X representa un grupo C = O, C-S-CH3, C-S, -C-NHOH；- R5 representa un átomo de hidrógeno o un grupo alquilo en C1 a C5；- R12 representa un átomo de hidrógeno, o un grupo -C-CO2-(CH3)3；- R1 a R4, R7 a R11 idénticos o diferentes, representan un átomo de hidrógeno, de halógeno (F, Cl, Br, I), un grupo hidroxi, alquilenohidroxi, alcinoalquilenohidroxi, alcinohidroxiciclohexilo, alquilo, alcoxi, alquilenoalcoxi, alquilenociano, estos radicales siendo de cadena recta o ramificada, en C1 a C18, el grupo alquileno siendo saturado o insaturado； dicha cadena sustituyéndose, en caso de que fuera necesario, por uno o varios grupos hidroxi o amino； un grupo trifluorometilo； un grupo -COM； -COOM； o -CH2COOM ( con M representando un átomo de hidrógeno, un grupo alquilo en C1
