Pyrimidine, pyridine and pyrazine amide derivatives substituted with thiazole or imidazole and related compounds such as inhibitors of ABL1, ABL2 and BCR-ABL1 for the treatment of cancer, specific viral infections and specific CNS disorders
FURET, Pascal,GROTZFELD, Robert Martin,JONES, Darryl Brynley,MANLEY, Paul,MARZINZIK, Andreas,MOUSSAOUI, Saliha,PELLE, Xavier Francois Andre,SALEM, Bahaa,SCHOEPFER, Joseph,JAHNKE, Wolfgang
申请号：
ES13730654
公开号：
ES2646777T3
申请日:
2013.05.09
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of the formula (I): ** Formula ** wherein: Y in each presentation is independently selected from N and CH； Y1 is selected from N and CR5； wherein R5 is selected from hydrogen, methoxy and imidazolyl； wherein the imidazolyl is unsubstituted or substituted with methyl； R1 is a 5- to 9-membered heteroaryl ring that incorporates one to four nitrogen, oxygen or sulfur atoms, wherein no more than one of the atoms is selected from an oxygen or sulfur； wherein the heteroaryl of R1 is unsubstituted or substituted with 1 to 3 R6 groups； R2 is selected from hydrogen, halogen, hydroxyl, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, methoxycarbonyl, 3,6-dihydro-2H-pyran-4-yl, tetrahydro- 2H-pyran-4-yl, tetrahydro-2H-pyran-4-yloxy and cyclobutyl； wherein this alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, cyclobutyl or tetrahydro-2Hpiran-4-yl of R2 may be unsubstituted or substituted with 1 to 3 groups independently selected from halogen, hydroxyl , cyano, alkoxy of 1 to 4 carbon atoms, morpholino, piperazinyl and NR5aR5b； wherein R5a is selected from hydrogen and alkyl of 1 to 4 carbon atoms； and R5b is selected from hydroxy-ethyl； wherein the R2 piperazinyl substituent may be unsubstituted or additionally substituted with alkyl of 1 to 4 carbon atoms； R3 is selected from hydrogen and halogen； R4 is selected from -SF5 and -Y2-CF2-Y3； R6 in each presentation is independently selected from hydrogen, hydroxyl, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, cyano, trifluoro-methyl, halogen, amino, methyl-carbonyl, methoxy carbonyl, cyclopropyl and pyrrolidinyl methyl； wherein this alkyl of 1 to 4 carbon atoms, or alkoxy of 1 to 4 carbon atoms of R6 is unsubstituted or substituted with 1 to 3 groups independently selected from halogen and hydroxyl； Y2 is selected from CF2, O and S (O) 0-2； and Y3 is selected from hydrogen, halogen, methyl, difluoro-methyl and trifluoro-methyl； Y4 is selected from N and CR2； Y5 and Y6 are independe
