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Heterobicyclic sulfonamide derivatives for the treatment of diabetes
专利权人:
F. HOFFMANN-LA ROCHE AG
发明人:
ACKERMANN, JEAN,BLEICHER, KONRAD,CECCARELLI, SIMONA,CHOMIENNE, ODILE,MATTEI, PATRIZIO,OBST SANDER, ULRIKE
申请号:
ES07726290
公开号:
ES2382214T3
申请日:
2007.02.02
申请国别(地区):
ES
年份:
2012
代理人:
摘要:
Compounds of the formula (I) ** Formula ** wherein V is N or -C (R7) -; W is a single bond or -C (R8R9) -; X is O, S, SO, SO2 or N (R10); Y is -C (R11R12) -, -C (R11R12) C (R13R14) -, -C (R11R12) C (R13R14) C (R15R16) -, -C (R11R12) C (R13R14) C (R15R16) C ( R17R18) - or -C (R11) = C (R12) -; R1, R2, R3, R4 and R5 independently of one another are hydrogen, halogen, cyano, hydroxy, lower alkyl, fluor-lower alkyl, lower alkoxy, fluor-lower alkoxy, lower alkyl-C (O), lower alkyl-C (O) -NH, lower alkyl- C (O) -N (lower alkyl), lower alkyl-S (O) 2, NH2-S (O) 2, N (H, lower alkyl) -S (O) 2 or N (lower alkyl) 2- S (O) 2, NH2-C (O), N (H, lower alkyl) -C (O), N (lower alkyl) 2-C (O), COOH or lower alkoxy -C (O), in which the lower alkyl is optionally substituted by hydroxy, NH2, N (H, lower alkyl) or N (lower alkyl) 2; R6 is an aryl or heteroaryl group, said aryl or heteroaryl group is optionally substituted by 1-4 substituents selected from the group consisting of halogen, hydroxy, cyano, lower alkyl, fluor-lower alkyl, lower alkoxy, fluor-lower alkoxy, alkyl lower-C (O), lower alkyl-C (O) -NH, lower alkyl-C (O) - N (lower alkyl), lower alkyl-S (O) 2, NH2-S (O) 2, N ( H, lower alkyl) -S (O) 2, N (lower alkyl) 2-S (O) 2, NH2-C (O), N (H, lower alkyl) -C (O), N (lower alkyl) 2-C (O), lower alkoxy-C (O), COOH, 1H-tetrazol-5-yl, 5-oxo-4H- [1,2,4] oxadiazol-3-yl, 5-oxo-4H- [1,2,4] thiadiazol-3-yl, 5-thioxo-4H- [1,2,4] oxadiazol-3-yl, 2-oxo-3H- [1,2,3,5] oxathiadiazol-4 -yl, SO3H, 3-hydroxy-isooxazol-5-yl, 6-oxo-6H-pyran-3-yl, 6-oxo-6H-pyran-2-yl, 2-oxo-2H-piran-3-yl , 2-oxo-2H-pyran-4-yl and P (O) (OCH2CH3) OH, wherein lower alkyl is optionally substituted by COOH, hydroxy, NH2, N (H, lower alkyl) or N (lower alkyl) 2 and where fluor-alkyl infe Rior is optionally substituted by hydroxy; R7 is hydrogen, halogen, lower alkyl, lower alkoxy, fluor-lower alkyl, fluor-lower alkoxy, hydroxy or hydroxy-lower alkyl; R8 and R9 independently of each other are hydrogen or lower alkyl; R10
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