KNUST HENNER,KOBLET ANDREAS,NETTEKOVEN MATTHIAS,RATNI HASANE,RIEMER CLAUS,VIFIAN WALTER
申请号：
IN5213/CHENP/2012
公开号：
IN2012CN05213A
申请日:
2012.06.14
申请国别(地区):
IN
年份:
2015
代理人:
摘要：
The present invention relates to compounds of formula Wherein R1 is hydrogen, halogen, cyano, lower alkyl or lower alkyl substituted by halogen n is 1,2 or 3, if n is 2 or 3, R1 can be different R2 is hydrogen or methyl R3 is (CH2)r-C(0)NH2 or (CH2)r-CN, wherein r is 1 or 2, or is a non aromatic heterocyclic group Wherein X isNorCH Y is -C(R)(R7)- -N(R7")-, -S(0)2 or O R6 is hydrogen, di-lower alkyl or =0 o and m may be independently from each other 0,1 or 2 p is 0,1 or 2 R is hydrogen, halogen, or lower alkyl R7 is hydrogen, halogen, hydroxy, lower alkyl substituted by hydroxy, cyano, or lower alkoxy Rr is hydrogen, -C(0)-lower alkyl, -C(0)0-lower alkyl, -C(0)CH20-lower alkyl, -C(0)CH2CN, or is -C(0)-cycloalkyl, cycloalkyl or -CH2-cycloalkyl, wherein the cycloalkyl groups are optionally substituted by halogen, lower alkoxy, lower alkyl substituted by halogen, cyano, -CH20-lower alkyl, or lower alkyl, or is -C(0)-heterocycloalkyl or heterocycloalkyl, or is -C(0)-heteroaryl or heteroaryl, which heterocycloalkyl or heteroaryl groups are optionally substituted by halogen, lower alkyl, =0, lower alkoxy, lower alkyl substituted by halogen, C(0)NH-Iower alkyl, C(0)NH2, C(0)-lower alkyl, S(0)2- lower alkyl or cyano Z is -0-, -NH- or -N(lower alkyl)- R4 is lower alkyl, lower alkyl substituted by halogen, lower alkyl substituted by hydroxy, lower alkyl substituted by cycloalkyl, (CH2)2>3-0-lower alkyl, CH(CH3)CH2-0-lower alkyl, (CH2)qCN, bicyclo[2.2.1]heptanyl, (CH2)q-cycloalkyl optionally substituted by lower alkyl, lower alkyl substituted by halogen,lower alkoxy or by halogen, or is (CH2)q-heterocycloalkyl or is (CH2)q-aryl, CH(lower alkyl)-aryl, CH(cycloalkyl)-aryl, or is (CH2)q-heteroaryl, which heterocycloalkyl, aryl or heteroaryl rings are optionally substituted by halogen, hydroxy, lower alkyl, lower alkyl substituted by halogen, S(0)2-lower alkyl, cyano or by lower alkoxy q is 0,1 or 2 or to a pharmaceutically active salt thereof. It has been f
