A compound of Formula I for use in a method of cancer treatment by modulating the Hedgehog signaling pathway: ** Formula ** wherein: Y1 and Y2 are independently selected from N and CH； R1 is selected from cyano, alkyl of 1 to 6 carbon atoms, alkyl of 1 to 6 carbon atoms substituted by halogen, alkoxy of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms substituted by halogen, dimethyl-amino, alkyl of 1 to 6 carbon atoms-sulfanyl and heterocycloalkyl of 3 to 8 carbon atoms optionally substituted with up to 2 alkyl radicals of 1 to 6 carbon atoms； R2 and R5 are independently selected from hydrogen, cyano, halo, alkyl of 1 to 6 carbon atoms, alkyl of 1 to 6 carbon atoms substituted by halogen, alkoxy of 1 to 6 carbon atoms, alkoxy of 1 to 6 atoms of carbon substituted with halogen, and dimethylamino； R3 and R4 are independently selected from hydrogen, halo, cyano, alkyl of 1 to 6 carbon atoms, alkyl of 1 to 6 carbon atoms substituted by halogen, alkoxy of 1 to 6 carbon atoms and alkoxy of 1 to 6 atoms of carbon substituted with halogen； R6 and R7 are independently selected from hydrogen, methyl chlorine, fluorine, bromine, trifluoromethyl and methoxy； with the proviso that R6 and R7 are not both hydrogen: and R8 is selected from hydrogen, methyl chlorine and trifluoromethyl； and R9 is selected from -S (O) 2R11, -C (O) R11, -NR12aR12b and -R11； wherein R11 is selected from thiomorpholino, sulfonomorpholino, sulfanomorpholino, morpholino, cyclohexyl, phenyl, azepan-1-yl, 2-oxopiperazin-1-yl, 1,4-oxazepan-4-yl, piperidin-1-yl, tetrahydro-2H-pyran-4-yl, piperidin-3-yl, piperazinyl, pyrrolidinyl and 1,4-diazepan-1-yl； and R12a and R12b are independently selected from isobutyl, hydroxyethyl, wherein said thiomorpholino, sulfonomorpholino, sulfanomorpholino, morpholino, cyclohexyl, phenyl, azepan-1-yl, 2- oxopiperazin-1-yl, 1,4-oxazepan-4 -yl, piperidin-1-yl, tetrahydro-2H-pyran-4-yl, piperidin-3-yl, piperazinyl, pyrrolidinyl or 1,4-diazepan-1-yl of R9 may be optionally subs
