GUILLERMO J. TEARNEY,TIMOTHY N. FORD,ROBERT W. CARRUTH,KENGYEH CHU
申请号：
US15111951
公开号：
US20160338578A1
申请日:
2015.01.15
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Methods, apparatus and devices for providing images based on the optical phase gradients within a biological sample can be provided. In one exemplary embodiment, a tethered and/or untethered capsule can be introduced into a biological specimen to acquire images by illuminating the specimen from at least two different angles, while an objective lens arrangement can relay an image from the illuminated sample to an imaging sensor array. The difference between images acquired using differing illumination angles and from the same position in the sample can indicate a phase contrast in a certain technique (e.g., oblique back illumination). The image focal plane provided by this exemplary arrangement/device, e.g., being planar by definition, constitutes only a small fraction of a volumetric specimen. To provide, e.g., three-dimensional or volumetric imaging, according to one exemplary embodiment of the present disclosure, it is possible to utilize a translational and rotational drive mechanism by which the thin plane of imaging is swept through the sample such that a large volume is imaged over time. To improve the coverage of the image plane sweep, according to yet another exemplary embodiment of present disclosure, it is possible to utilize a tilted camera and/or a non-paraxial optical lens arrangement, such that the image focal plane is not perpendicular to the optical axis of the objective lens arrangement.
