The present invention relates to a method and device for disinfecting a space and the objects present therein, wherein the method comprises at least the following steps of: (a) determining a first value of the relative humidity of the air in the space (b) vaporizing a disinfecting liquid in the space until a predetermined second value of the relative humidity of the air in the space is reached and (c) maintaining the relative humidity of the air at the second value for a predetermined time by means of vaporizing the disinfecting liquid, wherein the vaporization of the disinfecting liquid takes place by means of ultrasonic sound waves. With the method and device according to the invention all kinds of spaces of differing dimensions can be disinfected in very effective manner.